JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Although several epigenetic modulating drugs are suggested to target cancer stem cells (CSCs), additional identification of anti-CSC drugs is still necessary. Here we showed that JIB-04, a pan-selective inhibitor of histone demethylase(s), was identified as a small molecule that selectively target c...

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Vydáno v:Sci Rep
Hlavní autoři: Kim, Min Seong, Cho, Hye In, Yoon, Hee Jung, Ahn, Ye-Hyeon, Park, Eun Jung, Jin, Yan Hua, Jang, Yeun Kyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919936/
https://ncbi.nlm.nih.gov/pubmed/29700375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24903-0
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