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The small molecule JIB-04 disrupts O(2) binding in the Fe-dependent histone demethylase KDM4A/JMJD2A()
JIB-04, a specific inhibitor of the O(2)-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O(2) in KDM4A/JMJD2A through a continuous O(2)-consumption assay, X-ray crystal structure data, and molecular docking.
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5511625/ https://ncbi.nlm.nih.gov/pubmed/28144654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc09882g |
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