The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1‐PDGFRα and PDGFRα D842V

Activated forms of the platelet derived growth factor receptor alpha (PDGFRα) have been described in various tumors, including FIP1L1‐PDGFRα in patients with myeloproliferative diseases associated with hypereosinophilia and the PDGFRα(D842V) mutant in gastrointestinal stromal tumors and inflammatory...

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Publicat a:Mol Oncol
Autors principals: Noël, Laura A., Arts, Florence A., Montano-Almendras, Carmen P., Cox, Luk, Gielen, Olga, Toffalini, Federica, Marbehant, Catherine Y., Cools, Jan, Demoulin, Jean-Baptiste
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528641/
https://ncbi.nlm.nih.gov/pubmed/24618081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.02.003
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