The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo

AMN107 is a small molecule tyrosine kinase inhibitor developed, in the first instance, as a potent inhibitor of breakpoint cluster region-abelson (BCR-ABL). We tested its effectiveness against fusion tyrosine kinases TEL–platelet-derived growth factor receptorβ (TEL-PDGFRβ) and FIP1-like-1 (FIP1L1)–...

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Detalhes bibliográficos
Main Authors: Stover, Elizabeth H., Chen, Jing, Lee, Benjamin H., Cools, Jan, McDowell, Elizabeth, Adelsperger, Jennifer, Cullen, Dana, Coburn, Allison, Moore, Sandra A., Okabe, Rachel, Fabbro, Doriano, Manley, Paul W., Griffin, James D., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895333/
https://ncbi.nlm.nih.gov/pubmed/16030188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1932
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