The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation

BACKGROUND: Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRβ (TPβ, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRα (FPα) results from a deletion on chromosome 4q12 an...

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Bibliographic Details
Main Authors: Toffalini, Federica, Kallin, Anders, Vandenberghe, Peter, Pierre, Pascal, Michaux, Lucienne, Cools, Jan, Demoulin, Jean-Baptiste
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719031/
https://ncbi.nlm.nih.gov/pubmed/19644140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.001149
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