The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1‐PDGFRα and PDGFRα D842V

Activated forms of the platelet derived growth factor receptor alpha (PDGFRα) have been described in various tumors, including FIP1L1‐PDGFRα in patients with myeloproliferative diseases associated with hypereosinophilia and the PDGFRα(D842V) mutant in gastrointestinal stromal tumors and inflammatory...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Noël, Laura A., Arts, Florence A., Montano-Almendras, Carmen P., Cox, Luk, Gielen, Olga, Toffalini, Federica, Marbehant, Catherine Y., Cools, Jan, Demoulin, Jean-Baptiste
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528641/
https://ncbi.nlm.nih.gov/pubmed/24618081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.02.003
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