The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

The NTRK1 gene encodes Tropomyosin‐related kinase A (TRKA), the high‐affinity Nerve Growth Factor Receptor. NTRK1 was originally isolated from a colorectal carcinoma (CRC) sample as component of a somatic rearrangement (TPM3‐NTRK1) resulting in expression of the oncogenic chimeric protein TPM3‐TRKA,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Oncol
Egile Nagusiak: Ardini, Elena, Bosotti, Roberta, Borgia, Andrea Lombardi, De Ponti, Cristina, Somaschini, Alessio, Cammarota, Rosaria, Amboldi, Nadia, Raddrizzani, Laura, Milani, Andrea, Magnaghi, Paola, Ballinari, Dario, Casero, Daniele, Gasparri, Fabio, Banfi, Patrizia, Avanzi, Nilla, Saccardo, Maria B., Alzani, Rachele, Bandiera, Tiziano, Felder, Eduard, Donati, Daniele, Pesenti, Enrico, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Pierotti, Marco A., Siena, Salvatore, Veronese, Silvio, Galvani, Arturo, Isacchi, Antonella
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2014
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528583/
https://ncbi.nlm.nih.gov/pubmed/24962792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.001
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