The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

The NTRK1 gene encodes Tropomyosin‐related kinase A (TRKA), the high‐affinity Nerve Growth Factor Receptor. NTRK1 was originally isolated from a colorectal carcinoma (CRC) sample as component of a somatic rearrangement (TPM3‐NTRK1) resulting in expression of the oncogenic chimeric protein TPM3‐TRKA,...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Ardini, Elena, Bosotti, Roberta, Borgia, Andrea Lombardi, De Ponti, Cristina, Somaschini, Alessio, Cammarota, Rosaria, Amboldi, Nadia, Raddrizzani, Laura, Milani, Andrea, Magnaghi, Paola, Ballinari, Dario, Casero, Daniele, Gasparri, Fabio, Banfi, Patrizia, Avanzi, Nilla, Saccardo, Maria B., Alzani, Rachele, Bandiera, Tiziano, Felder, Eduard, Donati, Daniele, Pesenti, Enrico, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Pierotti, Marco A., Siena, Salvatore, Veronese, Silvio, Galvani, Arturo, Isacchi, Antonella
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528583/
https://ncbi.nlm.nih.gov/pubmed/24962792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.001
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