L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression

Regulatory T cell (T‐reg) enrichment in the tumor microenvironment is regarded as an important mechanism of tumor immune escape. Hence, the presence of T‐regs in highly malignant pancreatic ductal adenocarcinoma (PDAC) is correlated with short survival. Likewise, the adhesion molecule L1CAM is upreg...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Grage-Griebenow, Evelin, Jerg, Elfi, Gorys, Artur, Wicklein, Daniel, Wesch, Daniela, Freitag-Wolf, Sandra, Goebel, Lisa, Vogel, Ilka, Becker, Thomas, Ebsen, Michael, Röcken, Christoph, Altevogt, Peter, Schumacher, Udo, Schäfer, Heiner, Sebens, Susanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2014
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528528/
https://ncbi.nlm.nih.gov/pubmed/24746181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.03.001
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