L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression

Regulatory T cell (T‐reg) enrichment in the tumor microenvironment is regarded as an important mechanism of tumor immune escape. Hence, the presence of T‐regs in highly malignant pancreatic ductal adenocarcinoma (PDAC) is correlated with short survival. Likewise, the adhesion molecule L1CAM is upreg...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Grage-Griebenow, Evelin, Jerg, Elfi, Gorys, Artur, Wicklein, Daniel, Wesch, Daniela, Freitag-Wolf, Sandra, Goebel, Lisa, Vogel, Ilka, Becker, Thomas, Ebsen, Michael, Röcken, Christoph, Altevogt, Peter, Schumacher, Udo, Schäfer, Heiner, Sebens, Susanne
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2014
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528528/
https://ncbi.nlm.nih.gov/pubmed/24746181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.03.001
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