Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy

CUB‐domain‐containing‐protein‐1 (CDCP1) is an integral membrane protein whose expression is up‐regulated in various cancer types. Although high CDCP1 expression has been correlated with poor prognosis in lung, breast, pancreas, and renal cancer, its functional role in tumor formation or progression...

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Опубликовано в: :Mol Oncol
Главные авторы: Kollmorgen, Gwendlyn, Niederfellner, Gerhard, Lifke, Alexander, Spohn, Gloria J., Rieder, Natascha, Vega Harring, Suzana, Bauss, Frieder, Burtscher, Helmut, Lammers, Reiner, Bossenmaier, Birgit
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2013
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528444/
https://ncbi.nlm.nih.gov/pubmed/24055141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.08.009
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