Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating KRAS mutations and poor prognosis. Hence SS1P, a mesothelin‐targeted immunotoxin, could offer valuable treatment options for these patients, but its use in solid tumor therapy is hampered by high immunogenic...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Bauss, Frieder, Lechmann, Martin, Krippendorff, Ben-Fillippo, Staack, Roland, Herting, Frank, Festag, Matthias, Imhof-Jung, Sabine, Hesse, Friederike, Pompiati, Marc, Kollmorgen, Gwendlyn, da Silva Mateus Seidl, Rita, Bossenmaier, Birgit, Lau, Wilma, Schantz, Christian, Stracke, Jan O., Brinkmann, Ulrich, Onda, Masanori, Pastan, Ira, Bosslet, Klaus, Niederfellner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423209/
https://ncbi.nlm.nih.gov/pubmed/27507537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.07.003
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