A re-engineered immunotoxin shows promising preclinical activity in ovarian cancer

RG7787 is a re-engineered mesothelin-targeted immunotoxin with reduced immunogenicity composed of a humanized anti-mesothelin Fab fragment and a B-cell epitope silenced 24 kD fragment of Pseudomonas exotoxin A. High prevalence of mesothelin-positive cases and a large unmet medical need make ovarian...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kollmorgen, Gwendlyn, Palme, Klara, Seidl, Annette, Scheiblich, Stefan, Birzele, Fabian, Wilson, Sabine, Clemens, Christian, Voss, Edgar, Kaufmann, Martin, Hirzel, Klaus, Rieder, Natascha, Krippendorff, Ben-Fillippo, Herting, Frank, Niederfellner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741731/
https://ncbi.nlm.nih.gov/pubmed/29273809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17329-7
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