Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer

The TLR7 and TLR9 signalings are implicated in the regulation of the immune system through type-I interferon induction. Preclinical studies have demonstrated the immunomodulatory and antitumor effects of TLR7 and TLR9 agonists in combination with cetuximab. We tested the hypothesis that genetic vari...

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Veröffentlicht in:Int J Cancer
Hauptverfasser: Okazaki, Satoshi, Stintzing, Sebastian, Sunakawa, Yu, Cao, Shu, Zhang, Wu, Yang, Dongyun, Ning, Yan, Matsusaka, Satoshi, Berger, Martin D., Miyamoto, Yuji, Suenaga, Mitsukuni, Schirripa, Marta, West, Jordan D., Gopez, Roel, Tsuji, Akihito, Ichikawa, Wataru, Heinemann, Volker, DePaolo, R. William, Lenz, Heinz-Josef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528002/
https://ncbi.nlm.nih.gov/pubmed/28569041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30810
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