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EZH2 regulates the developmental timing of effectors of the pre-antigen receptor checkpoints

The histone methyltransferase EZH2 is required for B and T cell development; however the molecular mechanisms underlying this requirement remain elusive. In a murine model of lymphoid specific EZH2-deficiency we found that EZH2 was required for proper development of adaptive, but not innate, lymphoi...

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Pubblicato in:J Immunol
Autori principali: Jacobsen, Jennifer A., Woodard, Jennifer, Mandel, Malay, Clark, Marcus R., Bartom, Elizabeth T., Sigvardsson, Mikael, Kee, Barbara L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527689/
https://ncbi.nlm.nih.gov/pubmed/28490575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700319
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