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Epigenetic repression of the Igk locus by STAT5-mediated Ezh2 recruitment
During B lymphopoiesis, Igk recombination requires pre-B cell receptor (pre-BCR) expression and escape from interleukin 7 receptor (IL-7R) signaling. By activating the transcription factor STAT5, IL-7R signaling maintains proliferation and represses Igk germline transcription by unknown mechanisms....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233979/ https://ncbi.nlm.nih.gov/pubmed/22037603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2136 |
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