Histone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus

B lymphopoiesis requires that immunoglobulin genes be accessible to the RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin suggesting that additional mechanisms must restrict RAG-mediated DNA cleavage. Here, we demonstrate developmental downregulation of interleukin 7 (IL...

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Publicat a:Nat Immunol
Autors principals: Mandal, Malay, Hamel, Keith M., Maienschein-Cline, Mark, Tanaka, Azusa, Teng, Grace, Tuteja, Jigyasa H., Bunker, Jeffrey J., Bahroos, Neil, Eppig, John J., Schatz, David G., Clark, Marcus R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575638/
https://ncbi.nlm.nih.gov/pubmed/26301565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3249
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