CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis

In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both cell cycle exit and Igk recombination. Yet, how the pre-BCR mediates these functions remains unclear. Herein, we demonstrate that the pre-BCR initiated a feed-forward amplification loop mediated by th...

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Détails bibliographiques
Publié dans:Nat Immunol
Auteurs principaux: Mandal, Malay, Okoreeh, Michael K, Kennedy, Domenick E, Maienschein-Cline, Mark, Ai, Junting, McLean, Kaitlin C, Kaverina, Natalya, Veselits, Margaret, Aifantis, Iannis, Gounari, Fotini, Clark, Marcus R
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754289/
https://ncbi.nlm.nih.gov/pubmed/31477919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0468-0
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