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Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection

BACKGROUND: Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patterns along the genome – so-called ‘epialleles’ – offers greater insight into ep...

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Bibliografski detalji
Izdano u:BMC Bioinformatics
Glavni autori: Barrett, James E., Feber, Andrew, Herrero, Javier, Tanic, Miljana, Wilson, Gareth A., Swanton, Charles, Beck, Stephan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526259/
https://ncbi.nlm.nih.gov/pubmed/28743252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-1753-2
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