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Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection
BACKGROUND: Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patterns along the genome – so-called ‘epialleles’ – offers greater insight into ep...
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| Publié dans: | BMC Bioinformatics |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526259/ https://ncbi.nlm.nih.gov/pubmed/28743252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-1753-2 |
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