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Mechanisms that Synergistically Regulate η-Secretase Processing of APP and Aη-α Protein Levels: Relevance to Pathogenesis and Treatment of Alzheimer’s Disease

The pathophysiology of Alzheimer’s disease (AD) is characterized by the formation of cerebral β-amyloid plaque from a small peptide amyloid- (Aβ). Aβ is generated from the canonical amyloid-β precursor protein (APP) proteolysis pathway through β- and γ-secretases. Decreasing Aβ levels through target...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Discov Med
Prif Awduron: Ward, Joseph, Wang, Haizhi, Saunders, Aleister J., Tanzi, Rudolph E., Zhang, Can
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524192/
https://ncbi.nlm.nih.gov/pubmed/28371615
Tagiau: Ychwanegu Tag
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