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Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α and β-secretases: relevance to Alzheimer’s disease
Regulation of the amyloid precursor protein (APP) processing by α and β-secretases is of special interest to Alzheimer’s disease (AD), as these proteases prevent or mediate Aβ formation, respectively. Neuroinflammation is also implicated in AD. Our data demonstrate that the endogenous mediator of in...
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| Veröffentlicht in: | Neurobiol Aging |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743611/ https://ncbi.nlm.nih.gov/pubmed/29149631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.10.009 |
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