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Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments
Alzheimer's disease (AD) is characterized by the deposition of amyloid β (Aβ), a peptide generated from proteolytic processing of its precursor, amyloid precursor protein (APP). Canonical APP proteolysis occurs via α-, β-, and γ-secretases. APP is also actively degraded by protein degradation s...
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| Publicat a: | Biochemistry |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521409/ https://ncbi.nlm.nih.gov/pubmed/25910068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00329 |
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