Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments

Alzheimer's disease (AD) is characterized by the deposition of amyloid β (Aβ), a peptide generated from proteolytic processing of its precursor, amyloid precursor protein (APP). Canonical APP proteolysis occurs via α-, β-, and γ-secretases. APP is also actively degraded by protein degradation s...

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Vydáno v:Biochemistry
Hlavní autoři: Wang, Haizhi, Sang, Nianli, Zhang, Can, Raghupathi, Ramesh, Tanzi, Rudolph E., Saunders, Aleister
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521409/
https://ncbi.nlm.nih.gov/pubmed/25910068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00329
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