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C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.

BACKGROUND: Most early-onset forms of Alzheimer's disease are due to missense mutations located on two homologous proteins named presenilin 1 and 2 (PS1 and PS2). Several lines of evidence indicate that PS1 and PS2 undergo various post-transcriptional events including endoproteolytic cleavages,...

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Sonraí Bibleagrafaíochta
Main Authors: da Costa, C. A., Ancolio, K., Checler, F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Feinstein Institute for Medical Research 1999
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230295/
https://ncbi.nlm.nih.gov/pubmed/10404513
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