Effect of protein kinase A inhibitors on the production of Aβ40 and Aβ42 by human cells expressing normal and Alzheimer's disease-linked mutated βAPP and presenilin 1

समान संसाधन

• Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.
  द्वारा: Marambaud, P., और अन्य
  प्रकाशित: (1998)
• C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
  द्वारा: da Costa, C. A., और अन्य
  प्रकाशित: (1999)
• Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease
  द्वारा: Ancolio, K., और अन्य
  प्रकाशित: (1999)
• When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40. Talking Point on the role of presenilin mutations in Alzheimer disease
  द्वारा: Wolfe, Michael S
  प्रकाशित: (2007)
• Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
  द्वारा: Wanngren, Johanna, और अन्य
  प्रकाशित: (2014)