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Effect of protein kinase A inhibitors on the production of Aβ40 and Aβ42 by human cells expressing normal and Alzheimer's disease-linked mutated βAPP and presenilin 1

1. We previously established that the formation of both α- and β/γ-secretase-derived products generated by human embryonic kidney 293 cells (HEK293) expressing either wild type or mutant βAPP could be stimulated by agonists of the cyclic AMP/protein kinase A pathways. This cyclic AMP-dependent effec...

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Main Authors: Marambaud, P, Ancolio, K, Alves da Costa, C, Checler, F
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565882/
https://ncbi.nlm.nih.gov/pubmed/10205007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702406
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