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Mechanisms that Synergistically Regulate η-Secretase Processing of APP and Aη-α Protein Levels: Relevance to Pathogenesis and Treatment of Alzheimer’s Disease
The pathophysiology of Alzheimer’s disease (AD) is characterized by the formation of cerebral β-amyloid plaque from a small peptide amyloid- (Aβ). Aβ is generated from the canonical amyloid-β precursor protein (APP) proteolysis pathway through β- and γ-secretases. Decreasing Aβ levels through target...
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| Publicado no: | Discov Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524192/ https://ncbi.nlm.nih.gov/pubmed/28371615 |
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