Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells

The miR-483-3p is upregulated in several tumors, including liver tumors, where it inhibits TP53-dependent apoptosis by targeting the pro-apoptotic gene BBC3/PUMA. The transcriptional regulation of the miR-483-3p could be driven by the β-catenin/USF1 complex, independently from its host gene IGF2, an...

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Publicado en:Oncogenesis
Autores principales: Pepe, F, Pagotto, S, Soliman, S, Rossi, C, Lanuti, P, Braconi, C, Mariani-Costantini, R, Visone, R, Veronese, A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523068/
https://ncbi.nlm.nih.gov/pubmed/28481368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.35
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