Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma

The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in HCC cells carrying wild-type TP53 the steady activation of the miR-145 signali...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lupini, Laura, Pepe, Felice, Ferracin, Manuela, Braconi, Chiara, Callegari, Elisa, Pagotto, Sara, Spizzo, Riccardo, Zagatti, Barbara, Lanuti, Paola, Fornari, Francesca, Ghasemi, Reza, Mariani-Costantini, Renato, Bolondi, Luigi, Gramantieri, Laura, Calin, George A., Sabbioni, Silvia, Visone, Rosa, Veronese, Angelo, Negrini, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058762/
https://ncbi.nlm.nih.gov/pubmed/27120784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8913
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