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Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Choi, Jung-Suk, Kim, Seol, Motea, Edward, Berdis, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522278/
https://ncbi.nlm.nih.gov/pubmed/28489578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17254
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