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Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visu...

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Pubblicato in:Oncotarget
Autori principali: Choi, Jung-Suk, Kim, Seol, Motea, Edward, Berdis, Anthony
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522278/
https://ncbi.nlm.nih.gov/pubmed/28489578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17254
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