Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or...

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Publicado en:Diabetes
Autores principales: Lee, Hui-Young, Lee, Jae Sung, Alves, Tiago, Ladiges, Warren, Rabinovitch, Peter S., Jurczak, Michael J., Choi, Cheol Soo, Shulman, Gerald I., Samuel, Varman T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2017
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521865/
https://ncbi.nlm.nih.gov/pubmed/28476930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1334
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