Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

Aging-associated muscle insulin resistance has been hypothesized to be due to decreased mitochondrial function, secondary to cumulative free radical damage, leading to increased intramyocellular lipid content. To directly test this hypothesis we examined both in vivo and in vitro mitochondrial funct...

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Detalhes bibliográficos
Main Authors: Lee, Hui-Young, Choi, Cheol Soo, Birkenfeld, Andreas L., Alves, Tiago C., Jornayvaz, Francois R., Jurczak, Michael J., Zhang, Dongyan, Woo, Dong Kyun, Shadel, Gerald S., Ladiges, Warren, Rabinovitch, Peter S., Santos, Janine H., Petersen, Kitt F., Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013349/
https://ncbi.nlm.nih.gov/pubmed/21109199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.004
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