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Lipid-induced insulin resistance: unravelling the mechanism

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles through inhibition of glycolysis at key points. However, work over the past two decades has shown that lipid-induced insul...

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Detalhes bibliográficos
Main Authors: Samuel, Varman T, Petersen, Kitt Falk, Shulman, Gerald I
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995547/
https://ncbi.nlm.nih.gov/pubmed/20609972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(10)60408-4
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