Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

Aging-associated muscle insulin resistance has been hypothesized to be due to decreased mitochondrial function, secondary to cumulative free radical damage, leading to increased intramyocellular lipid content. To directly test this hypothesis we examined both in vivo and in vitro mitochondrial funct...

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Autors principals: Lee, Hui-Young, Choi, Cheol Soo, Birkenfeld, Andreas L., Alves, Tiago C., Jornayvaz, Francois R., Jurczak, Michael J., Zhang, Dongyan, Woo, Dong Kyun, Shadel, Gerald S., Ladiges, Warren, Rabinovitch, Peter S., Santos, Janine H., Petersen, Kitt F., Samuel, Varman T., Shulman, Gerald I.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013349/
https://ncbi.nlm.nih.gov/pubmed/21109199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.004
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