Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Lee, Hui-Young, Lee, Jae Sung, Alves, Tiago, Ladiges, Warren, Rabinovitch, Peter S., Jurczak, Michael J., Choi, Cheol Soo, Shulman, Gerald I., Samuel, Varman T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521865/
https://ncbi.nlm.nih.gov/pubmed/28476930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1334
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge