Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance. We assessed insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrial-targeted catalase (MCAT) that were fed regular chow (RC) or a high-fat diet (HFD) or...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Lee, Hui-Young, Lee, Jae Sung, Alves, Tiago, Ladiges, Warren, Rabinovitch, Peter S., Jurczak, Michael J., Choi, Cheol Soo, Shulman, Gerald I., Samuel, Varman T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521865/
https://ncbi.nlm.nih.gov/pubmed/28476930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1334
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