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Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of Parkinson’s disease (PD) with late-onset and autosomal-dominant inheritance. LRRK2 belongs to the ROCO superfamily of proteins, characterized by a Ras-of-complex (Roc) GTPase domain in tandem with a C-terminal-...
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| Pubblicato in: | Adv Neurobiol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5521808/ https://ncbi.nlm.nih.gov/pubmed/28353279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-49969-7_4 |
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