GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, including functional Roc GTPase and protein kin...

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Autors principals: Xiong, Yulan, Coombes, Candice E., Kilaru, Austin, Li, Xiaojie, Gitler, Aaron D., Bowers, William J., Dawson, Valina L., Dawson, Ted M., Moore, Darren J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851569/
https://ncbi.nlm.nih.gov/pubmed/20386743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000902
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