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GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, including functional Roc GTPase and protein kin...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851569/ https://ncbi.nlm.nih.gov/pubmed/20386743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000902 |
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