Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

Lead (Pb) is a known nephrotoxicant that causes damage to proximal tubular cells. Autophagy has an important protective role in various renal injuries, but the role of autophagy in Pb-elicited nephrotoxicity remains largely unknown. In this study, Pb promoted the accumulation of autophagosomes in pr...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Song, Xiang-Bin, Liu, Gang, Liu, Fei, Yan, Zhen-Gui, Wang, Zhen-Yong, Liu, Zong-Ping, Wang, Lin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520918/
https://ncbi.nlm.nih.gov/pubmed/28594408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.262
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