Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in photoreceptor cell death and vision loss both in animal models and in affected patients. The rd10 mouse, which carries a missense mutation in the Pde6b gene, has been used to characterize the underlying pathoph...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Rodríguez-Muela, N, Hernández-Pinto, A M, Serrano-Puebla, A, García-Ledo, L, Latorre, S H, de la Rosa, E J, Boya, P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326579/
https://ncbi.nlm.nih.gov/pubmed/25501597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.203
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