Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

Lead (Pb) is a known nephrotoxicant that causes damage to proximal tubular cells. Autophagy has an important protective role in various renal injuries, but the role of autophagy in Pb-elicited nephrotoxicity remains largely unknown. In this study, Pb promoted the accumulation of autophagosomes in pr...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Song, Xiang-Bin, Liu, Gang, Liu, Fei, Yan, Zhen-Gui, Wang, Zhen-Yong, Liu, Zong-Ping, Wang, Lin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520918/
https://ncbi.nlm.nih.gov/pubmed/28594408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.262
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