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Sonic Hedgehog activates Phospholipase A2 to enhance Smoothened ciliary translocation

The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and independent routes, with G protein-independent canonical signaling to Gli effectors requiring Smo accumulation in the primary cilium. Mechanisms c...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Arensdorf, Angela M., Dillard, Miriam E., Menke, Jacob M., Frank, Matthew W., Rock, Charles O., Ogden, Stacey K.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520665/
https://ncbi.nlm.nih.gov/pubmed/28591579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.033
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