Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation

The Sonic Hedgehog (Shh) pathway conducts primarily in the primary cilium and plays important roles in cell proliferation, individual development, and tumorigenesis. Shh ligand binding with its ciliary membrane-localized transmembrane receptor Patched1 results in the removal of Patched1 from and the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Boyan, Zhuang, Tenghan, Lin, Qiaoyu, Yang, Biying, Xu, Xiaowei, Xin, Guangwei, Zhu, Shicong, Wang, Gang, Yu, Bin, Zhang, Tingting, Jiang, Qing, Zhang, Chuanmao
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338837/
https://ncbi.nlm.nih.gov/pubmed/30598432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804042116
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