Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation

The Sonic Hedgehog (Shh) pathway conducts primarily in the primary cilium and plays important roles in cell proliferation, individual development, and tumorigenesis. Shh ligand binding with its ciliary membrane-localized transmembrane receptor Patched1 results in the removal of Patched1 from and the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Boyan, Zhuang, Tenghan, Lin, Qiaoyu, Yang, Biying, Xu, Xiaowei, Xin, Guangwei, Zhu, Shicong, Wang, Gang, Yu, Bin, Zhang, Tingting, Jiang, Qing, Zhang, Chuanmao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338837/
https://ncbi.nlm.nih.gov/pubmed/30598432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804042116
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