Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner

Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer effects by causing damage to cellular DNA. However, systemic treatment damages DNA not only in cancer, but also in healthy cells, resulting in the progression of serious side effects and limiting efficacy of the...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogenesis
Hauptverfasser: Wamsley, J J, Gary, C, Biktasova, A, Hajek, M, Bellinger, G, Virk, R, Issaeva, N, Yarbrough, W G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520489/
https://ncbi.nlm.nih.gov/pubmed/28394357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.12
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