Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner

Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer effects by causing damage to cellular DNA. However, systemic treatment damages DNA not only in cancer, but also in healthy cells, resulting in the progression of serious side effects and limiting efficacy of the...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Wamsley, J J, Gary, C, Biktasova, A, Hajek, M, Bellinger, G, Virk, R, Issaeva, N, Yarbrough, W G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520489/
https://ncbi.nlm.nih.gov/pubmed/28394357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.12
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