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Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
While p53 activation has long been studied, the mechanisms by which its targets genes are restored to their pre-activation state are less clear. We report here that TAF1 phosphorylates p53 at Thr55, leading to dissociation of p53 from the p21 promoter and inactivation of transcription late in the DN...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919457/ https://ncbi.nlm.nih.gov/pubmed/24289924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.031 |
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