Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Retinoid X receptor-alpha (RXRα) binds to DNA either as homodimers or heterodimers, but it also forms homotetramers whose function is poorly defined. We previously discovered that an N-terminally-cleaved form of RXRα (tRXRα), produced in tumour cells, activates phosphoinositide 3-kinase (PI3K) signa...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Chen, Liqun, Aleshin, Alexander E., Alitongbieke, Gulimiran, Zhou, Yuqi, Zhang, Xindao, Ye, Xiaohong, Hu, Mengjie, Ren, Gaoang, Chen, Ziwen, Ma, Yue, Zhang, Duo, Liu, Shuai, Gao, Weiwei, Cai, Lijun, Wu, Lingjuan, Zeng, Zhiping, Jiang, Fuquan, Liu, Jie, Zhou, Hu, Cadwell, Gregory, Liddington, Robert C., Su, Ying, Zhang, Xiao-kun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520057/
https://ncbi.nlm.nih.gov/pubmed/28714476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16066
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