NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell

Retinoid X receptor α (RXRα) and its N-terminally truncated version tRXRα play important roles in tumorigenesis, while some RXRα ligands possess potent anti-cancer activities by targeting and modulating the tumorigenic effects of RXRα and tRXRα. Here we describe NSC-640358 (N-6), a thiazolyl-pyrazol...

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Detalhes bibliográficos
Publicado no:Protein Cell
Main Authors: Chen, Fan, Chen, Jiebo, Lin, Jiacheng, Cheltsov, Anton V., Xu, Lin, Chen, Ya, Zeng, Zhiping, Chen, Liqun, Huang, Mingfeng, Hu, Mengjie, Ye, Xiaohong, Zhou, Yuqi, Wang, Guanghui, Su, Ying, Zhang, Long, Zhou, Fangfang, Zhang, Xiao-kun, Zhou, Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Higher Education Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537469/
https://ncbi.nlm.nih.gov/pubmed/26156677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0178-9
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