Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Retinoid X receptor-alpha (RXRα) binds to DNA either as homodimers or heterodimers, but it also forms homotetramers whose function is poorly defined. We previously discovered that an N-terminally-cleaved form of RXRα (tRXRα), produced in tumour cells, activates phosphoinositide 3-kinase (PI3K) signa...

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Publicado no:Nat Commun
Main Authors: Chen, Liqun, Aleshin, Alexander E., Alitongbieke, Gulimiran, Zhou, Yuqi, Zhang, Xindao, Ye, Xiaohong, Hu, Mengjie, Ren, Gaoang, Chen, Ziwen, Ma, Yue, Zhang, Duo, Liu, Shuai, Gao, Weiwei, Cai, Lijun, Wu, Lingjuan, Zeng, Zhiping, Jiang, Fuquan, Liu, Jie, Zhou, Hu, Cadwell, Gregory, Liddington, Robert C., Su, Ying, Zhang, Xiao-kun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520057/
https://ncbi.nlm.nih.gov/pubmed/28714476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16066
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