Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site of RXRα

Retinoid X receptor-alpha (RXRα), an intriguing and unique drug target, can serve as an intracellular target mediating the anti-cancer effects of certain non-steroidal anti-inflammatory drugs (NSAIDs), including Sulindac. We report the synthesis and characterization of two new Sulindac analogs, K-80...

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Detalhes bibliográficos
Main Authors: Chen, Liqun, Wang, Zhi-Gang, Aleshin, Alexander, Chen, Fan, Chen, Jiebo, Jiang, Fuquan, Alitongbieke, Gulimiran, Zeng, Zhiping, Ma, Yue, Huang, Mingfeng, Zhou, Hu, Cadwell, Gregory, Zheng, Jian-Feng, Huang, Pei-Qiang, Liddington, Robert, Zhang, Xiao-kun, Su, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035439/
https://ncbi.nlm.nih.gov/pubmed/24704507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.02.017
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